1/1/2024 0 Comments Down in bermuda igg![]() A Toronto-based company has proposed running a cable through the Arctic that connects Tokyo and London. Sharks aside, the Internet is ever at risk of being disrupted by boat anchors, trawling by fishing vessels, and natural disasters. While the ocean is free of construction equipment that might otherwise combine to form Devastator, there are many ongoing aquatic threats to the submarine cables. It seems like every couple of years, some well-meaning construction worker puts his bulldozer in gear and kills Netflix for the whole continent. THE INTERNET IS AS VULNERABLE UNDERWATER AS IT IS UNDERGROUND. In response, companies such as Google are shielding their cables in shark-proof wire wrappers. (My theory.) The point remains that sharks are chewing on the Internet, and sometimes damage it. Maybe they’re trying to disrupt our communications infrastructure before mounting a land-based assault. Maybe it has something to do with electromagnetic fields. ![]() There’s disagreement as to why, exactly, sharks like gnawing on submarine communications cables. Though per-mile prices for installation change depending on total length and destination, running a cable across the ocean invariably costs hundreds of millions of dollars. Cables located at shallow depths are buried beneath the ocean floor using high pressure water jets. The size difference is related to simple vulnerability-there’s not much going on 8000 feet below sea level consequently, there’s less need for galvanized shielding wire. The diameter of a shallow water cable is about the same as a soda can, while deep water cables are much thinner-about the size of a Magic Marker. It’s more than a matter of dropping wires with anvils attached to them-the cables must generally be run across flat surfaces of the ocean floor, and care is taken to avoid coral reefs, sunken ships, fish beds, and other ecological habitats and general obstructions. The cables are installed by special boats called cable-layers. In total, they are hundreds of thousands of miles long and can be as deep as Everest Is tall. Combined detection of all three antibody isotypes saves time and precious patient samples and provides a dynamic, comprehensive profile of humoral immune responses over time following natural infection with SARS-CoV-2 or immunization with COVID-19 vaccines.Ninety-nine percent of international data is transmitted by wires at the bottom of the ocean called submarine communications cables. The iQue ® SARS-CoV-2 (IgG, IgM and IgA) kit provides a rapid, robust and sensitive serological assay for the measurement of IgG, IgM and IgA anti-SARS-CoV-2 Spike RBD antibodies in a single well of a 96 or 384-well plate with antibody detection levels in the pg/mL range. Do not allow multiplexing analysis of IgG, IgM and IgA antibodies.Can be labor-intensive and may not support high-throughput applications.There are several methods for detecting anti-SARS-CoV-2 Spike RBD IgG, IgM or IgA antibodies, including a traditional enzyme-linked immunosorbent assay (ELISA), lateral flow immunoassay and flow cytometry. Serological testing to quantitate the three major isotypes (IgG, IgM and IgA) of antibodies specific for SARS-CoV-2 Spike RBD can be used to facilitate characterization and monitor the duration of antibody responses in both COVID-19 patients and vaccinated individuals, detect asymptomatic infections and survey past infection prevalence in a population. Antibodies against the SARS-CoV-2 Spike RBD generally have potent viral neutralizing activity and correlate with protective immunity against the virus. The SARS-CoV-2 Spike RBD mediates viral entry into human cells by binding to the angiotensin-converting enzyme 2 (ACE2) and is the primary target of many COVID-19 vaccines currently in use. Because development of a humoral immune response against this virus is critical for protection, there is an ongoing need to accurately assess the quantity and duration of antibody responses against SARS-CoV-2, particularly antibodies targeting the SARS-CoV-2 Spike protein receptor binding domain (RBD). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to persist due to constant mutation and evasion. Advance your COVID-19 research by obtaining a comprehensive profile of antibodies against SARS-CoV-2 using a multiplex and high throughput serological assay.
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